Mannose
Mannose is a sugar monomer of the aldohexose series of carbohydrates. It is a C-2 epimer of glucose. It is important in human metabolism, especially in the glycosylation of certain proteins. Several congenital disorders of glycosylation are associated with mutations in enzymes involved in metabolism.
This sugar commonly exists as two different sized rings, the pyranose (six-membered) form and the furanose (five-membered) form. Each ring closure can have either an alpha or beta configuration at the anomeric position. The chemical rapidly undergoes isomerization among these four forms.
While much of the mannose used in glycosylation is believed to be derived from glucose, in cultured hepatoma (cancerous cells from the liver) cells, most of the mannose for glycoprotein biosynthesis comes from extracellular mannose, not glucose. Many of the glycoproteins produced in the liver are secreted into the bloodstream, so dietary mannose is distributed throughout the body.
Recombinant proteins produced in yeast may be subject to mannose addition in patterns different from those used by mammalian cells. This difference in recombinant proteins from those normally produced in mammalian organisms may influence the effectiveness of vaccines.
Source: Wikipedia
D-mannose is used to treat a rare disease called carbohydrate-deficient glycoprotein syndrome type 1b. This disease is passed down through families. It makes you lose protein through the intestines. Some reports say D-mannose slows down this protein loss and makes your liver work better. It may also reduce bleeding disorders and low blood sugar in people with this disease. Preliminary clinical trails in Europe show that it may also treat or prevent urinary tract infections (UTIs). Research suggests the supplementstops certain bacteria from sticking to the bladder walls. Scientists think that the bacteria stick to the sugar instead. This helps the bacteria leave the body through your urine. Fewer bacteria in the bladder lowers your risk of a urinary tract infection. Some studies suggest this sugar may play a useful role as a “prebiotic.” Prebiotics are substances that may help your body by stimulating the growth of “good” bacteria in your digestive system. In some lab studies and studies in mice, D-mannose components were shown to increase the growth of “good” bacteria. This suggests it may have some use for people with dysbiosis, an imbalance in good and bad bacteria.
Source: WebMD
Chromatogram(s) using Benson Polymeric Columns
Part No.:
Eluent:
Flow Rate:
Detection:
Temperature:
Sample Size:
Column Size:
Resin Type:
DI H2O
0.5 ml/min
RI
85 C
20 ul, 30 mg/ml
300 x 7.8 mm
6% Ca
2 – Maltose
3 – Glucose
4 – Mannose
5 – Fructose
6 – Ribitol
Part No.:
Eluent:
Flow Rate:
Detection:
Temperature:
Sample Size:
Column Size:
Resin Type:
DI H2O
0.4 ml/min
RI
90 C
20 ul, 30 mg/ml
300 x 7.8 mm
6% Pb
2 – Maltose
3 – Xylose
4 – Galactose
5 – Mannose
6 – Glycerol
Part No.:
Eluent:
Flow Rate:
Detection:
Temperature:
Sample Size:
Column Size:
Resin Type:
DI H2O
0.6 ml/min
RI
85 C
20 ul, 30 mg/ml
300 x 7.8 mm
8% Ca
2 – Maltose
3 – Glucose
4 – Mannose
5 – Fructose
6 – Ribitol
You must be logged in to post a comment.