Mannitol (also referred to as mannite or manna sugar) is a white, crystalline solid that looks and tastes sweet like sucrose. It was originally isolated from the secretions of the flowering ash and called manna after its resemblance to the Biblical food. In plants it is used to alleviate osmotic stress. Mannitol has several industrial uses, but is mainly used to produce tablets of medicine. Its fetal safety is “C” (FDA pregnancy category: risk not ruled out) in Briggs’ Reference Guide to Fetal and Neonatal Risk. Mannitol is classified as a sugar alcohol; that is, it is derived from a sugar (mannose) by reduction. Other sugar alcohols include xylitol and sorbitol. Mannitol and sorbitol are isomers, the only difference being the orientation of the hydroxyl group on carbon 2.
It is on the World Health Organization’s List of Essential Medicines, a list of the most important medications needed in a basic health system. It was originally isolated from the flowering ash and called manna after its supposed resemblance to the Biblical food.
Source: Wikipedia
Mannitol
Chromatogram(s) using Benson Polymeric Columns
Part No.:
Eluent:
Flow Rate:
Detection:
Temperature:
Sample Size:
Column Size:
Resin Type:
DI H2O
0.5 ml/min
RI
80 C
20 ul, 30 mg/ml
300 x 7.8 mm
6% Ca
2 – DP4
3 – DP3
4 – Maltose
5 – Glucose
6 – Galactose
7 – Fructose
8 – Mannitol
9 – Sorbitol
Part No.:
Eluent:
Flow Rate:
Detection:
Temperature:
Sample Size:
Column Size:
Resin Type:
DI H2O
0.6 ml/min
RI
85 C
20 ul, 30 mg/ml
300 x 7.8 mm
8% Ca
2 – Sorbitol
Part No.:
Eluent:
Flow Rate:
Detection:
Temperature:
Sample Size:
Column Size:
Resin Type:
DI H2O
0.4 ml/min
RI
85 C
20 ul, 30 mg/ml
250 x 4.0 mm
8% Ca
2 – Sorbitol
Part No.:
Eluent:
Flow Rate:
Detection:
Temperature:
Sample Size:
Column Size:
Resin Type:
DI H2O
0.6 ml/min
RI
80 C
20 ul, 30 mg/ml
200 x 7.8 mm
8% Pb
2 – Maltitol
3 – 1,6-GPS Isomalt
4 – Mannitol
5 – Sorbitol
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