Lactulose is a non-absortable sugar used in the treatment of constipation and hepatic encephalopathy. It can be used by mouth or for hepatic encephalopathy either by mouth or in the rectum. It generally begins working after eight to twelve hours but may take up to two days to improve constipation.
Common side effects include abdominal bloating and cramps. There is the potential for electrolyte problems to occur as a result of diarrhea it produces. No evidence of harm to the baby has been found when used during pregnancy. It is generally regarded as okay during breastfeeding. It is classified as an osmotic laxative.
Lactulose was first made in 1929. It is on the World Health Organization’s List of Essential Medicines, the most important medications needed in a basic health system. It is available as a generic medication. The wholesale price is about 0.18 USD per dose. In the United States 30 doses of the liquid is about 20 USD. It is made from the milk sugar lactose.
Lactulose is used in the treatment of chronic constipation in patients of all ages as a long-term treatment. It is used for chronic idiopathic constipation, i.e. chronic constipation occurring without any identifiable cause. Lactulose may be used to counter the constipating effects of opioids, and in the symptomatic treatment of hemorrhoids as a stool softener.
Source: Wikipedia
Lactulose
Chromatogram(s) using Benson Polymeric Columns
Part No.:
Eluent:
Flow Rate:
Detection:
Temperature:
Sample Size:
Column Size:
Resin Type:
DI H2O
0.4 ml/min
RI
90 C
20 ul, 30 mg/ml
300 x 7.8 mm
6% Ca
2 – Maltose
3 – Lactulose
4 – Glucose
5 – Fructose
Part No.:
Eluent:
Flow Rate:
Detection:
Temperature:
Sample Size:
Column Size:
Resin Type:
DI H2O
0.4 ml/min
RI
80 C
20 ul, 30 mg/ml
300 x 7.8 mm
6% Ca
2 – Maltose
3 – Lactulose
4 – Glucose
5 – Xylose
6 – Arabinose
7 – Ribitol
8 – Arabitol
9 – Xylitol
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